Hypothesis about the possible mechanisms of therapeutic action of Serenoa repens hexane extract on the hypertrophied bladder in accordance with the pathogenesis of its dysfunction caused by bladder outlet obstruction.

Introduction. Traditionally it is believed that the therapeutic effect of hexane extract Serenoa repens (HSRE) in patients with benign prostatic hyperplasia realized due to its on prostate cells. However, literature there data about possible HSRE not only prostate, but also directly bladder. This paper summarizes and analyzes cellular mechanisms action bladder under development infravesical obstruction (bladder outlet – BOO). Materials methods. Literature from PubMed eLibrary.ru databases for a 25-years period related study pathogenesis dysfunction BOO, molecular by which pathological adaptive processes cells are realized, as well influence these analyzed. Results. The concept pleiotropic various links caused BOO has been formed. main are: antioxidant anti-inflammatory effects components, regulatory cell growth proliferation factors transcription factors. All this reduces cytotoxic oxidative stress developing IVO, contributing more active detrusor smooth muscle consequence complex maintain contractile function state adaptation increased stress, BOO. Conclusions. present hypothesis direct hypertrophied based an understanding general biological allows us explain better results previous clinical studies assess prospects expanding scope further drug application.